| Batting—M. Young, Texas | .331 |
| Home runs—A. Rodriguez, New York | 48 |
| Runs batted in—D. Ortiz, Boston | 148 |
| Runs—A. Rodriguez, New York | 124 |
| Hits—M. Young, Texas | 221 |
| Stolen bases—C. Figgins, Los Angeles | 62 |
| Doubles—M. Tejada, Baltimore | 50 |
| Triples—C. Crawford, Tampa Bay | 15 |
| Slugging percentage—A. Rodriguez, New York | .610 |
A.L. Pitching
| Wins—B. Colon, Los Angeles | 21 |
| Earned run average—K. Millwood, Cleveland | 2.86 |
| Strikeouts—J. Santana, Minnesota | 238 |
| Innings pitched—M. Buehrle, Chicago | 236.2 |
| Complete games—R. Halladay, Toronto | 5 |
| Shutouts—J. Garland, Chicago | 3 |
| Saves—F. Rodriguez, Los Angeles and B. Wickman, Cleveland | 45 |
