The 28th Annual American Music Awards were presented on January 8, 2001.
| POP/ROCK | | Favorite Male Artist | Kid Rock | | Favorite Female Artist | Faith Hill | | Favorite Band, Duo, or Group | Backstreet Boys | | Favorite Album | Human Clay, Creed | | Favorite New Artist | 3 Doors Down |
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| SOUL/RHYTHM & BLUES | | Favorite Male Artist | Brian McKnight | | Favorite Female Artist | Toni Braxton | | Favorite Band, Duo, or Group | Destiny’s Child | | Favorite Album | Heat, Toni Braxton | | Favorite New Artist | Donnell Jones |
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| COUNTRY | | Favorite Male Artist | Tim McGraw | | Favorite Female Artist | Faith Hill | | Favorite Band, Duo, or Group | Dixie Chicks | | Favorite Album | Breathe, Faith Hill | | Favorite New Artist | Billy Gilman |
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| ADULT CONTEMPORARY | | Favorite Artist | Celine Dion |
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| RAP/HIP-HOP | |
| LATIN MUSIC | | Favorite Artist | Enrique Iglesias |
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| SOUNDTRACK | | Favorite Soundtrack | Mission: Impossible 2 |
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| ALTERNATIVE MUSIC | |
| AWARD OF MERIT | Janet Jackson |
