The 34th Annual American Music Awards were presented on November 21, 2006.
| POP/ROCK | | Favorite Male Artist | Sean Paul | | Favorite Female Artist | Kelly Clarkson | | Favorite Band, Duo, or Group | Red Hot Chili Peppers | | Favorite Album | All the Right Reasons, Nickelback | |
| SOUL/RHYTHM & BLUES | | Favorite Male Artist | Jamie Foxx | | Favorite Female Artist | Mary J. Blige | | Favorite Album | The Breakthrough, Mary J. Blige | |
| COUNTRY | | Favorite Male Artist | Toby Keith | | Favorite Female Artist | Faith Hill | | Favorite Band, Duo, or Group | Rascal Flatts | | Favorite Album | Greatest Hits Volume 2, Tim McGraw | |
| RAP/HIP-HOP | | Favorite Male Artist | Eminem | | Favorite Band, Duo, or Group | The Black Eyed Peas | | Favorite Album | Monkey Business, The Black Eyed Peas | |
| ALTERNATIVE | | Favorite Artist | Red Hot Chili Peppers | |
| ADULT CONTEMPORARY | | Favorite Artist | Kelly Clarkson | |
| LATIN MUSIC | |
| CONTEMPORARY INSPIRATIONAL | | Favorite Artist | Kirk Franklin | |
| BREAKTHROUGH FAVORITE NEW ARTIST | |
